SLA
SLA
At CIC Neurosciences, we conduct three types of studies: therapeutic studies (both industry-sponsored and academic), and pathophysiological studies aimed at unraveling the fundamental mechanisms of diseases in order to advance our understanding and improve patient care.
Industrial therapeutic studies
Academic therapeutic studies
Pathophysiological Studies
DAZALS
A multicenter, randomized, double-blind, placebo-controlled Phase 2 study to evaluate the safety and efficacy of CORT113176 (Dazucorilant) in patients with amyotrophic lateral sclerosis (ALS).
🎯: To evaluate the efficacy and safety of CORT113176 in patients with amyotrophic lateral sclerosis (ALS).
📝: Currently being monitored
COMPLETED
A Phase IIa, double-blind, randomized, placebo-controlled study with an active-treatment extension phase to evaluate the safety, tolerability, efficacy, pharmacokinetics, and immunogenicity of ARGX-119 in participants with amyotrophic lateral sclerosis
🎯: To evaluate the safety and tolerability of ARGX-119 in participants with ALS
⏳: Currently being added
SEALS
A Phase II, double-blind, randomized, placebo-controlled, multicenter study evaluating the efficacy, tolerability, safety, and pharmacokinetics of repeated intravenous infusions of NX210c in adult patients with Amyotrophic Lateral Sclerosis (ALS)
🎯: To assess the effect of the NX210c on blood neurofilament light chain (NfL) or on a biomarker of blood-brain barrier (BBB) integrity in blood and cerebrospinal fluid (CSF) at the 6-week follow-up.
⏳: Currently being added
CERMALS
The Role of Insulin Signaling Pathways in Maintaining Reinnervation and Motor Function in Kennedy’s Syndrome and ALS
🎯: To determine the role of insulin signaling pathways in maintaining muscle reinnervation and motor function in ALS.
⏳: Currently being added
STRATALS
Stratification of presymptomatic amyotrophic lateral sclerosis: development of new imaging biomarkers
🎯: Study of the disease progression during the presymptomatic phase of ALS.
⏳: Currently being added
FG COALS
A Franco-German cohort study to identify factors associated with weight loss in amyotrophic lateral sclerosis
🎯: Identify biological, genetic, and imaging biomarkers associated with weight loss that could help prevent it and that could potentially be used to personalize dietary advice, thereby positively impacting disease progression and survival.
⏳: Currently being added
At CIC Neurosciences, we conduct three types of studies: therapeutic studies (both industry-sponsored and academic), and pathophysiological studies aimed at unraveling the fundamental mechanisms of diseases in order to advance our understanding and improve patient care.
Industrial therapeutic studies
DAZALS
A multicenter, randomized, double-blind, placebo-controlled Phase 2 study to evaluate the safety and efficacy of CORT113176 (Dazucorilant) in patients with amyotrophic lateral sclerosis (ALS).
🎯: To evaluate the efficacy and safety of CORT113176 in patients with amyotrophic lateral sclerosis (ALS).
📝: Currently being monitored
COMPLETED
A Phase IIa, double-blind, randomized, placebo-controlled study with an active-treatment extension phase to evaluate the safety, tolerability, efficacy, pharmacokinetics, and immunogenicity of ARGX-119 in participants with amyotrophic lateral sclerosis
🎯: To evaluate the safety and tolerability of ARGX-119 in participants with ALS
⏳: Currently being added
SEALS
A Phase II, double-blind, randomized, placebo-controlled, multicenter study evaluating the efficacy, tolerability, safety, and pharmacokinetics of repeated intravenous infusions of NX210c in adult patients with Amyotrophic Lateral Sclerosis (ALS)
🎯: To assess the effect of the NX210c on blood neurofilament light chain (NfL) or on a biomarker of blood-brain barrier (BBB) integrity in blood and cerebrospinal fluid (CSF) at the 6-week follow-up.
⏳: Currently being added
Pathophysiological Studies
CERMALS
The Role of Insulin Signaling Pathways in Maintaining Reinnervation and Motor Function in Kennedy’s Syndrome and ALS
🎯: To determine the role of insulin signaling pathways in maintaining muscle reinnervation and motor function in ALS.
⏳: Currently being added
STRATALS
Stratification of presymptomatic amyotrophic lateral sclerosis: development of new imaging biomarkers
🎯: Study of the disease progression during the presymptomatic phase of ALS.
⏳: Currently being added
FG COALS
A Franco-German cohort study to identify factors associated with weight loss in amyotrophic lateral sclerosis
🎯: Identify biological, genetic, and imaging biomarkers associated with weight loss that could help prevent it and that could potentially be used to personalize dietary advice, thereby positively impacting disease progression and survival.
⏳: Currently being added